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Dickey's lab began learning mucin secretion 20 years back and previously determined The important thing genes and proteins concerned, displaying how synaptotagmin and a SNARE complicated, similar to that present in neurons, add to The true secret technique of Ca2+-brought on membrane fusion.
Consequently, blocking the exercise of Syt2 should stop sudden huge mucin release with no impairing slow, regular baseline mucin secretion that is necessary for airway health and fitness."
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The Dickey laboratory then employed an aerosolized Edition within a mouse design to confirm the drug decreased mucin secretion and airway blockage by mucus. Importantly, SP9 did not have sp9 an effect on the gradual-release pathway for typical mucin secretion.
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